Expression of Telomerase RNA Component Correlates with the MIB-1 Proliferation Index in Ependymomas
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چکیده
منابع مشابه
MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27 Protein Expression in Nephroblastoma
Purpose: A number of studies have indicated that the tumor proliferation marker MIB-1 and cell cycle inhibitor p27 expression are of prognostic importance in a variety of cancers. The present study was performed to evaluate the prognostic value of these molecules in Wilms’ tumors. Experimental Design: MIB-1 and p27 expressions were investigated by the means of immunohistochemical analysis of 62...
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Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETAR in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETAR in EOC.Methods: Thirty patie...
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Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by telomerase, a ribonucleic acid (RNA)-protein complex. Here, the cloning of the RNA component of human telomerase, termed hTR, is described. The template region of hTR encompasses 11 nucleotides (5'-CUAACCCUAAC) complementary to the human ...
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Elongation of human telomeres requires the enzymatic activity of the telomerase holoenzyme. In vitro, telomerase activity can be reconstituted by the catalytic subunit (hTERT) and the RNA subunit (called hTERC, hTER, or hTR). However, the routes of the RNA and protein components of telomerase from their generation to assembly into telomerase appear to be complex and likely to be highly regulate...
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For prognostic analyses of p53 alterations (p53 gene mutations + p53 immunopositivity) and Mib-1 proliferation index, we investigated 42 primary malignant lipomatous tumors for which complete clinical data and a long follow-up were available. p53 gene mutations were investigated by PCR-single strand conformation polymorphism-sequencing analysis, and immunohistochemistry was used to determine p5...
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ژورنال
عنوان ژورنال: Journal of Neuropathology and Experimental Neurology
سال: 1997
ISSN: 0022-3069
DOI: 10.1097/00005072-199710000-00008